A friend asked a very interesting question out of nowhere. He asked if there was a comic book character is the best to switch places with. Now, the problem is you get all of their weaknesses and villains. So while fire may not be an issue to you, if you choose to be Martian Manhunter then you're just going to have to deal with it. What we have here are a list of three people who may have a great life or set of powers are not ideal to switch places with.
Let's start this with everyone's favorite wall-crawling superhero, The Amazing (and sometimes Spectacular) Spider-Man. His power set would be easy to conceal. He's super strong, but not so strong that you have to worry about bumping into stuff and breaking it, his agility and speed would be amazing (pun intended) if you wanted to play sports recreationally (no way you pass any enhancement tests with his messed up DNA), and being able to stick to walls would be great to do just for fun.
The problem with Peter Parker is you also get the Spider-Man curse. You will have no time for a personal life because every two seconds someone will be getting mugged and you'll have to stop it or Norman Osborn will get bored and try to throw your significant other off a bridge because someone gave him the green pills and not the blue pills. Let's say for the sake of argument you don't have to worry about power and responsibility and you decide to not be a hero and just live your life, at some point you have to deal with a family of jerks who are almost as strong as the Hulk that are going to try and consume your energy because that's just what they do. Even if you beat them all and save the world, you'll still have to pick up the Daily Bugle and see someone write about how you're menace even though you saved people. His life kind of stinks.
The best there is at what you do and what you do is pretty great. First off, the healing factor. You'll never get sick, tired, and you can heal from almost everything. Granted, it'll hurt like heck, but you get to survive and walk away within minutes. With your heightened senses you'd never need glasses or any kind. The claws are kind of just there. Unless you're a hunter or an assassin you don't really need them. That said, you're pretty much invincible, why not become a hired killer? It's the perfect job.
Sabretooth will come and try to kill for no reason. He knows he can't really kill you, but he's going to try and inflict as much pain on you as humanly possible. Why? Because he's an a-hole. Not only Sabretooth, but you'll have a ton of people who are going to try and kill you for no rational reason. Wolverine said it perfectly, "When you're the best, there's always someone trying to take their shot at you". Well, that is never going to stop until you're dead. Oh, wait, you can't die so it will never stop. Since you can't die, you also get to see all of your loved one get old and pass on while you will live on and look thirty when you're over a hundred.
Not much with powers except when the moon was a certain shape, you'd become faster, stronger, and could see the future a bit. What makes Moon Knight so great is his vast amount of money. He may not have Bruce Wayne money, but he still has a vast amount of cool gadgets that, weapons and vehicles that Bruce Wayne does. He even has some other weapons that Batman doesn't. The best part of Moon Knight is unlike Batman, he kills his villains so they don't come back. So Joker would be a giant stain in the middle of the street if he was a Moon Knight villain.
You'd end up being completely insane. Moon Knight is just one of the three personalities that he is stuck with. On top of that, their is the god Khonshu that gave you your powers that may or may not be real. So you have three voices screaming in your head and possibly fictional god telling you to do a bunch of stuff to make him happy. And Khonshu isn't just a voice. You will actually see him. Sometimes he looks like the disfigured villain you killed dressed as something goofy and inappropriate, sometimes he's just a random thing, and then there's the Khonshu that looks like the Egyptian god in a suit. Either way, he's there and he's there permanently. Treat him right and you will receive power, but treat him wrong and he will kill you and resurrect you to teach you a lesson or just flat out abandon you.